Novel Miniaturized, Electrothermal Activated, Optically Controlled, Highthroughput Noninvasive Drug Infusion Pump

Our objective is to develop a novel, compact, lightweight, and disposable Micropump for safe and precise delivery of pharmacological agents and drugs. The proposed technology will couple recently reported electrokinetic phenomena, electrothermal flow, with an inline flow sensor based on Laser-Induced Fluorescence Photobleaching Anemometry and a feedback controller for automatic, digital control of infusion flow rate. The safety of the system is ensured via precise flow rate control for a specific drug to minimize dosage error. The pump will be designed to provide flow rates in the range of 1-500 ml/hr. The program objectives will be accomplished via several innovations (a) MEMS/microfluidics based architecture, (b) plastic laminates-based fabrication (target cost < $10/piece), and (c) simulation-based design for optimal performance. During Phase I, we will demonstrate two critical components of the system, Micropump and flow sensor. Preliminary Design Review document based on detailed analysis of pumping requirements will be prepared. A design strategy for improved safety features will be developed. In Phase II, integrated system development will be the major focus, with comprehensive design of feedback controller, scale-up and system integration to meet DoD needs. A multidisciplinary team with proven expertise in biomicrosystems engineering, optics and microfabrication has been assembled. The research work will leverage on existing microfluidic product development projects.