Smart Hemodynamic Monitoring System for Critical Care Air Transport Team (CCATT)

Defense Research Technologies, Inc. proposes to analyze, design, simulate, and evaluate the feasibility of a smart hemodynamic monitoring system for the Critical Care Air Transport Teams (CCATTs). Of particular interest is our ability 1) to non-invasively measure bulk density, viscosity, specific heat, and concentrations of CO2, O2, 2) to use these non-invasive measurements in calculating short and long term fluctuations in cardiac output and hemodynamic values over multiple hours in flight, and 3) to use decision tree analysis to provide continuous smart informed alerts and recommendations about hemodynamic stability (pre-and post-interventions). Our proposed integrated system consists of: 1) a microfluidic gas sensor-analyzer with breath-by-breath outputs of bulk gas properties from which individual species concentrations are calculated; 2) compensated spirometer flow measurements for density and viscosity; 3) calculation of pulmonary functions - respiratory quotient and metabolic; 3) hemodynamic sensors for cardiac and blood measurements; 4) single breath calculational process for cardiac output, mixed-venous and end-capillary CO2, O2 pressures, physiologic deadspace, alveolar ventilation rate, CO2 production, and O2 consumption; and 5) an intelligent decision tree analysis for recommending treatment options. We will design, model, and simulate a prototype of a low cost, continuous, safe, non-invasive hemodynamic monitor, which makes simultaneous measurements at 30Hz.