Real-Time Single Particle Bioaerosol Detector

This Small Business Innovation Research Phase II proposal seeks build upon the Phase I results and develop a multi-spectral prototype instrument for measuring the angular light scattering patterns from individual flowing aerosol particles. The sensor utilizes sophisticated image processing and multivariate algorithms to discriminate among biological and non-biological particulate matter. The ultimate sensor is envisioned to be a compact, modular instrument that may be incorporated into HVAC systems for continuous monitoring and advanced warning of furtive releases of biological warfare agents. Successful threat detection would initiate isolation protocols and appropriate countermeasures. In addition to developing a multi-spectral light scattering apparatus, we will assess the feasibility of integrating a fluorescence-based approach, providing an orthogonal measurement to enhance the discrimination capabilities. Laboratory testing of the Phase II prototype will quantify system performance and provide a critical design review that will ultimately result in a Phase III commercialization product. Working with our commercialization partner, the successful prototype sensor will be transitioned to the marketplace for air quality monitoring and building security applications. Furthermore, we will market the Phase III sensor as a complementary instrument for enhanced discrimination in existing programs such as the Joint Biological Point Detection System (JBPDS), Immune Building, and BioWatch.