Proteomic Biomarker Diagnostics for Detection and Prognosis of Cancer using MEMS Biosensor Arrays

BioScale Inc. proposes to develop a rapid, multiplexed protein biomarker detection system for disease diagnosis and prognosis. This system is based on a resonant MEMS sensor with an engineered capture surface capable of sensitive and specific measurements of analyte in solution. The Phase I program demonstrated detection of a model protein in concentrations relevant to clinical applications with a total time to result of less than one hour. Additionally, multiple samples with different analyte concentrations were analyzed simultaneously on the same chip along with several controls. The Phase II program will build on these results to develop a multiplexed detection system for prostate cancer. The technical effort will focus on developing assays for three to five candidate biomarkers. The program will culminate with simultaneous detection of multiple biomarkers spiked in blood on a single chip.