SBIR/STTR Research Award
IGF OT IGF MULTIPLEXED HIGH CONTENT ASSAY TO MEASURE CELLULAR STRESS MECHANISMS FOR PREDICTIVE TOXICOLOGY STUDIES
Award amount
$1,499,999Program and phase
SBIR · Phase IIAward year
2016Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- CAIRN BIOSCIENCES INC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- LWZWY2J1M2J4
- Solicitation number
- Not reported
- Topic code
- NIDA
Research abstract
The Contractor currently provides a high throughput assay platform that rapidly pinpoints compound mechanism of action and toxicity liabilities through its unique ability to monitor multiple facets of previously inaccessible biology in live cells in real time Through this SBIR Phase II contract the Contractor s existing platform will be applied to the development of a novel live cell multiplexed fluorescent assay that reports an aggregate of at least distinct readouts of cellular stress and organelle homeostasis per well A panel of multicolor cell stress reporters will be generated and stably integrated into cell lines relevant for compound toxicity evaluation The resulting panel of multicolor stable reporter cell lines will be used as the foundation for our multiplexed assay Our assay will be validated by testing its response to tool compounds known to induce cellular stress Our assay s suitability for high throughput screening will be evaluated by running a sample pilot screen followed by scaling to at least samples day throughput in well plate format with full assay automation The Contractor s proposed assay will benefit public health by reducing the time and cost to pinpoint toxicities of pharmaceutical and environmental chemicals thus improving our ability to identify beneficial therapeutics and to proactively manage harmful environmental toxins
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- A MICROFLUIDIC AND MACHINE LEARNING-ENABLED SMARTLAB FOR AUTONOMOUS REMOTE EXECUTION AND ITERATION OF MULTISCALE LIVE CELL ASSAYS FOR DRUG DISCOVERY
- High-throughput profiling of compound abuse liabilities and identification of addiction-related drug targets using an iPSC-enabled platform
- Multiplexed high-content assay for toxicity profiling using live iPSC-derived cardiomyocyte lines with lineage-specific barcoding
- IGF OT IGF MULTIPLEXED HIGH CONTENT ASSAY FOR TOXICITY MECHANISMS AND PHENOTYPES IN LIVE IPSC DERIVED CARDIAC CELLS
- IGF OT IGF A MULTIFUNCTIONAL REUSABLE AND AUTOMATED MICROFLUIDIC SMART PLATE FOR HIGH THROUGHPUT LIVE CELL ASSAYS
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression
- Building and testing the Life Enhancement and Advocacy Programming digital training tool (LEAPLink) to better serve people with lived experience of homelessness and substance use disorder
- A digital intervention to decrease self-stigma among pregnant and postpartum women with opioid use disorder
- Development of medication for the treatment of respiratory depression due to opioid (prescribed or illicit) overdose/multidrug (polysubstance) overdose in a hospital or community setting.
- Creation and Validation of the Dose-Opioid-Source Evaluation tool (DOSE) - a Robust Opioid Use Clinical Outcome Assessment for Qualification as an FDA Medical Device Development Tool (MDDT)
Research funding history
9 SBIR/STTR records share this UEI (2015–2021). Reported award amounts total $5,740,087. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, National Science Foundation