NEUTRALIZATION OF HIV BY GENETICALLY-MODIFIED LACTOBACIL

Not Available Electrochemical systems are among the most promising candidates for the miniaturization of chemical and biological sensors due to their close association with today's advanced semiconductor technology. Further miniaturization of the electrochemical part is expected to enable on-chip integration of the sensors. The result will be a highly portable microanalytical sensor system with fast response time and high selectivity. It is proposed to use arrays of carbon nanofibers as ultimate nanosize electrodes. The fibers can be produced well aligned and with good mechanical strength on a variety of substrates. MER's experience in the fabrication and tailoring of carbon nanofibers will be utilized to produce nanofiber structures, which meet the requirements for nanoelectrode arrays. Existing electronic designs will be used to interface the microelectrode arrays and to obtain electrochemical data. Redox modifying compounds will be immobilized on the electrode surface to improve selectivity and sensitivity of the electrode arrays towards biological agents. BENEFITS: Besides an improvement of the safety of battlefield personnel, handheld biosensors with fast response time and good selectivity could be used in clinical health care applications, pharmaceutical production and in agricultural applications. These devices could also be used for the detection of chemical agents.