A smart needle guide template for MRI-guided transperineal prostate biopsy

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) and the Surgical Navigation and Robotics Laboratory (SNR) at Brigham and Women's Hospital (BWH) propose to develop and test a Smart Template to guide transperineal targeted prostate biopsiesand subsequent therapy under magnetic resonance imaging (MRI). The project aims to solve the problem of poor diagnostic yield in prostate biopsies. As many as half of cancers in the prostate are missed in an initial diagnostic biopsy, resulting in repeated biopsy, oversampling, and delayed treatment. The proposed device provides precise control of needle entry location based on diagnostic and intra-operative (MRI), leading to precise targeting of suspicious tissue. SNR has been developing and testing prototypes of the device for several years. In this STTR program, the technology will be transferred to PSI for advanced engineering development and commercialization. Because SNR has tested prototypes of the device, we have identified the issues to be add