DEVELOPMENT OF A GROUP A STREP SUBUNIT VACCINE

Not Available CombiMatrix employs CMOS integrated circuitry to produce analog VLSI arrays of individually addressable electrodes. Existing electrode array chips will be modified to make arrays of nanometer-scale ultramicro electrodes. These chips will be used to develop assays for chemical and biological warfare agents. Assays will use highly selective immunochemical methods. The advantageous electrochemical properties of nanodes will be exploited to improve the limits of detection and speed of these biochip sensor devices. Further, CombiMatrix hardware and manufacturing methods allow for multiplexing numerous assays onto a single biochip. Multiplexed assays will be demonstrated. BENEFITS: This proposal will have direct application to development of portable environmental sensor devices, as well as biochip applications such as genomics, proteomics, and drug discovery.