Amplification of Molecular Signal Using Highly Stabilized Acoustic Wave Devices

U.S. forces require rapid, early and accurate pathogen detection systems designed for use in extreme combat situations. Numerous options to deliver weaponized pathogens drives the necessity for U.S. forces to have technology to detect infectious pathogens.TPL has conceived a unique methodology for amplifying the presence of a pathogen without multiplying physical number of pathogens. TPL proposes using our highly stabilized acoustic wave sensor system that significantly reduces or eliminates inherentsusceptibility to various interferents (temperature, shock, internally and externally generated spurious noise, etc) to detect the biomolecular amplification cascade. Combined, these two innovations address the most critical issues in pathogen detection.In Phase I, TPL will demonstrate the feasibility of these two critical elements in a biosensor instrumentation system. The biomolecular amplification technique will be verified. The ability of the biosensor to detect the amplification agents will beconfirmed.The P.I. is responsible for the development of the highly stabilized acoustic wave sensor overcoming environmental sensitivities, which have plagued similar sensor developments. TPL will continue its collaborative relationship with the staff at theUniversity of New Mexico's Health Science Center in the use of this sensor for biochemistry-related measurements. The major commercial application of the proposed amplification of molecular signal using highly stabilized acoustic wave sensor will be inthe rapid, early and accurate infectious pathogen. Safeguarding all urban office and commercial facilities of high priority in the United States. These types of pathogen detection systems could be used in a mobile hand held units or could be used as fixedinstallations where large groups of people pass through. The number of this type of sensor system that could be sold to government and private companies could conceivably be in the hundreds of thousands.