SBIR/STTR Research Award
SBIR Phase II: Detection and Identification Instrument for Single Molecule Analysis
Award amount
$100,000Program and phase
SBIR · Phase IAward year
2003Award details
- Awarding agency
- National Science Foundation
- Branch
- Not reported
- Recipient company
- RADIATION MONITORING DEVICES, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- SCKQA85YU4U4
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
This Small Business Innovation Research (SBIR) Phase II project proposes to develop a novel, low cost laboratory instrument for genetic analysis and single molecule studies. The technology is suitable for the detection and identification of DNA and RNA through fluorescent hybridization probes without the need for Polymerase Chain Reaction (PCR) amplification, or for proteins and small molecules through fluorescence immunoassays. The general scheme is based on single molecule detection (SMD) and utilizes the two-color cross-correlation spectroscopy (TC-FCCS) technique with coincident detection analysis scheme to simultaneously probe ten focal regions of a microfluidic assay. High efficiency single photon detectivity Geiger mode microavalanche photodiode (uAPD) arrays will function as detection elements. The commercial application of this project will be on biological and medical research, and on the drug development process. Examples of potential applications range from the study of conformational dynamics and interactions of macromolecules to biochemical kinetics of single molecules.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Transparent Conducting Oxide Based On-Chip Modulators for Applications at Cryogenic Temperatures
- Conformal Neutron Supermirrors by Atomic Layer Deposition
- Lead Chalcogenide Mid-Wave Infrared High Detectivity Detectors
- Enabling Precise Multi-Layer Optical Coatings on Highly Curved Lenses with Atomic Layer Deposition
- Lithium Niobate Crystal Growth and Wafer Fabrication
Research funding history
930 SBIR/STTR records share this UEI (1983–2026). Reported award amounts total $346,950,619. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Energy, Department of Health and Human Services, Department of Defense, National Aeronautics and Space Administration, National Science Foundation, Department of Homeland Security