SBIR/STTR Research Award
TOPIC 394 - A VERSATILE RADIATION-TRIGGERED PHOSPHOR PLATFORM FOR LOCALIZED ANTI-CANCER THERAPY
Award amount
$299,799Program and phase
SBIR · Phase IAward year
2019Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- PACT & HEALTH LLC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- PYHDD9LBJ8B4
- Solicitation number
- Not reported
- Topic code
- NCI
Research abstract
The goal of this project is to fabricate a novel nanoscintillator photosensitizer complex for X ray excited photodynamic therapyXPDTHereina low dose of X raysltGyis used to excite scintillating nanoparticleswhich downconvert ionizing radiation to UV vis lightPhotosensitizers loaded onto the nanoscintillator complex absorb this UV vis emission and generate cytotoxic reactive oxygen speciesROSin the tumor microenvironmentThe long term objective is to overcome the depth limitation of light activated photosensitizers through an unique X ray excited photodynamic therapy platformXPDTwherein a low dose of focal or generalized radiation can eradicate localized or metastatic pancreatic adenocarcinomasrespectivelyTechnological innovations include the fabrication of a novel nanocomplexcomparison between nanocomplexes using a novel scintillation detection platformin vitro and in vivo testingand the use of a novel excitation X ray source
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- TOPIC 366: I-PARTS INTEGRATED PLATFORM FOR ANTI-CANCER RADIATION THERAPEUTICS SCREENING
- I PARTS INTEGRATED PLATFORM FOR ANTI CANCER RADIATION THERAPEUTICS SCREENING
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Mini-reflectance confocal microscope (Mini-RCM) for aiding skin cancer diagnosis and treatment
- Development of small molecule therapeutics targeting AR-V7 for prostate cancer
- Decentralized Clinical Trial of Effectiveness of EnergyPoints App to Guide Acupressure Use for Fatigue and Sleep Disturbances in Cancer Survivors
- Optimized targeted radiotherapy of pancreatic cancer
- Adaptive imaging for pioneering multiplexed spatial profiling of tumors and tissues for cancer research and diagnosis
Research funding history
3 SBIR/STTR records share this UEI (2017–2019). Reported award amounts total $2,562,837. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services