Quantum Dot Sensors for Superfund Priority Substances

DESCRIPTION (provided by applicant): The principal aim of this project is to obtain proof-of-concept for a new nanotechnology-based sensor material for rapid and sensitive fluorescence detection of polycyclic aromatic hydrocarbons (PAHs) and polychloro biphenyls (PCBs). Simple, cheap and safe methods to detect and quantify these toxic substances, which rank high in the ATSDR Substance Priority List and contaminate many US Superfund priority sites, are highly sought after. Emission-based methods using sensitive and specific fluorescent probes offer improved means to do this. Our plan will create new chemosensors useful for detecting and quantifying PAHs and PCBs, including on-site rapid qualitative assays of soil and water of contaminated sites and as analytical probes for the spectrofluorometric quantitization of these high-ranking toxins. In Phase I of this project we will conduct a proof-of-concept study to synthesize new sensor probes and validate their emission properties when challenged with PAH and PCBanalytes. The new sensor materials will be useful as rapid and sensitive probes in analytical tests and assays for monitoring the hazardous substances at contaminated Superfund sites. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Toxic polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) pollute Superfund sites in the United States. This research and development project will create new sensor probes to help detect, locate and monitor these toxic chemicals for improved Superfund site cleanup.