SBIR/STTR Research Award
Semiconductor Electronic Label-Free Assay (SELFA) for Diagnosing Heart Disease
Award amount
$212,718Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- SELFA, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- HL14-011
- Topic code
- NHLBI
Research abstract
DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In United States and Europe alone, about 15 million patients are annually admitted to emergency departments with acute coronary syndrome.These patients are immediately screened for potential acute myocardial infarction (AMI) via electrocardiogram and biomarker detection in blood samples. Due to its high specificity and elevated concentrations in blood for hours past an incident, cardiac troponin I (cTnI) has become one of the most reliable biomarkers for diagnosing AMI where a cTnI concentration of less than 0.10 ng/mL is considered a negative result, while a cTnI concentration of 0.10 ng/mL or greater is considered a positive result. Furthermore, recent studies have shown that cTnI could also be used for AMI risk stratification. However, for this intended use, ultra-sensitive assays are required to detect slightly elevated levels of cTnI in blood samples. Currently there are
Technology keywords
Not reported
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