SBIR/STTR Research Award
DNP-enhanced Tissue HRMAS MRS - Towards Measurements of Single-Cell Metabolomics
Award amount
$205,508Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- BRIDGE 12 TECHNOLOGIES, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- KU5VWM3D5TJ8
- Solicitation number
- PA13-234
- Topic code
- NIGMS
Research abstract
DESCRIPTION (provided by applicant): The proposed research focuses on the development DNP-enhanced high-resolution magic-angle-spinning (HRMAS) magnetic resonance spectroscopy (MRS) to quantify cellular metabolities within intact prostate tissue. This willallow the study of micro-dissected pure pathological features, which is currently not possible due to the sensitivity limitations of the method. With DNP, the inherently small signal intensities in an NMR/MRS experiment can be drastically enhanced. In recent years, DNP has proven to be a robust method to increase signal intensities in NMR experiments in laboratories around the world and substantial progress has been made in adapting DNP for solution-state NMR spectroscopy. The enhancements available through DNP (gt 80) are in Iarge contrast to the sensitivity gain that can be expected from a cryo-probe. However, since (human) tissue has the characteristics corresponding of solid and solution-state NMR samples, specific technology has to be developed to
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
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Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
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Research funding history
38 SBIR/STTR records share this UEI (2010–2025). Reported award amounts total $18,895,835. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, Department of Energy, Department of Defense, National Science Foundation