SBIR/STTR Research Award

Humanized Antibody Therapeutic to Improve Cardiac Function Following Myocardial I

Award identifier 26cb166a764239ab526262562b55cb9e0b06ba538bb63d481ab0899f23d31004Awarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$2,998,259

Program and phase

SBIR · Phase II

Award year

2014

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
DECIMMUNE THERAPEUTICS, INC
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
HL13-016
Topic code
NHLBI

Research abstract

DESCRIPTION (provided by applicant): Project Summary/Abstract Acute myocardial infarction (AMI) affects over 1 million US individuals a year and at the present there are no preventive therapeutics other than direct percutaneous coronary intervention. DecImmune's long-term goal is to develop therapeutics to reduce the severe lethal reperfusion injury that follows removal of coronary artery blockage. This goal is based on our identification of a novel pathway that is activated during reperfusion of ischemic tissues and development of a peptide mimetope (N2) and monoclonal antibodies that block inflammation. The current application is a re-submission of our Phase IIB application of 2012. Our studies from Phase I demonstrated that the novel pathway we identifiedin rodents is conserved in humans. In Phase II, we showed that both the peptide (N2) and our murine monoclonal antibody against N2 (21G6) were protective during acute myocardial infarction and that a therapeutic candidate monoclonal antibody has been

Technology keywords

Not reported

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Agency intelligence

Department of Health and Human Services

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