Whole Blood Sensor for Creatinine

The concentration of creatinine in serum is the most widely used and commonly acceptedmeasure of renal function in clinical medicine. Serum urea level along with serum creatinine level arefrequently used for the evaluation of renal function, since the levels of these two waste products helpin the differential diagnosis of pre-renal, renal and post-renal hyperuremia. Presently there is nocreatinine analyzer that can handle whole blood. The laboratory turn around time may range from 15-90min even for a simple electrolyte analysis, which is not acceptable for treatment of acute renal failures.The applicants believe that the development of a suitable creatinine sensor that can be integrated intoexisting blood gas/electrolyte analyzers is a significant technological innovation with a potentially largecommercial application. Their approach to this problem is to develop sensors based on enzymaticdecomposition of creatinine followed by the electrochemical detection of one of the reaction products.Phase I aims include development of the sensor Membranes and tests on the key sensor parameters.