Commercialization Readiness of Wearable Optically Pumped Magnetoencephalography

Abstract Magnetoencephalography (MEG) has established itself as an indispensable tool for functional brain imaging, offering unparalleled spatial and temporal resolution while being non-invasive. Despite its advantages, current MEG systems based on superconducting quantum interference devices (SQUIDs) are cost-prohibitive and lack adaptability, particularly for pediatric populations. This project focuses on the development of a wearable MEG system based on Optically Pumped Magnetometer (OPM) technology, a novel alternative to traditional SQUID magnetometers. This innovation eliminates the need for cryogenic cooling, thereby overcoming significant limitations associated with traditional MEG systems. Using OPMs has enabled the development of a cost-effective, flexible, and high-resolution MEG system (OPM-MEG). Our technology aims to match the spatial resolution of invasive techniques such as Electrocorticography (ECoG), while maintaining the non-invasive nature of traditional MEG. Additionally, it features a flexible helmet, accommodating individuals of all ages and allowing for head movement during scanning—an important advancement in neuroimaging technologies. Building on our successful Phase IIB project, where we developed and deployed prototype high-density OPM-MEG systems in leading neuroscience laboratories, the current project aims to finalize the essential steps for the commercialization of this groundbreaking technology.