SBIR/STTR Research Award
Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing.
Award amount
$1,464,412Program and phase
SBIR · Phase II – Direct to Phase IIAward year
2020Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- ENCODIA INC
- Proposal award date
- 2020-09-15
- Contract end date
- 2022-08-31
- UEI
- XQMHALBLACC9
- Solicitation number
- PA19-272
- Topic code
- 400
Research abstract
ABSTRACT
More accessible and cost-effective technologies for analysis of the proteome would
accelerate biological and medical research. The goal of this proposal is to develop
enzymatic reagents to enable creation of a highly-scalable digital protein analysis
technology. The approach is broadly applicable and greatly improves upon cost,
sensitivity, usability, and throughput of current approaches.NARRATIVE
This proposal is to develop reagents/technology to enable user-friendly, high-throughput
analysis of proteins. By making information about proteins more easily accessible, this
technology has the potential to advance basic research in almost every area in
molecular life sciences, as well as applied and clinical research, including drug target
discovery and drug development.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- HT protein profiling with a Next-Gen Protein Assay (NGPA)
- Directed evolution of N-terminal amino acid binding proteins for application to protein sequencing
- Development of Engineered Trypsin for Proteomics Sample Prep.
- Development of Population Level Serotyping Technology and Antibody Profiling for Infectious Pathogens with focus on Influenza and SARS-CoV-2
- Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Platform for Optimizing Yield and Quality of Therapeutic AAV Vector Manufacturing via Synthetic Helper Genes
- Ultra-low-temperature (6 K) static NMR-DNP for metalloproteins, proteins in cells, and materials
- Dynamical Diffraction Analysis for 3D Electron Crystallography
- Synthetic biology approaches for bio-orthogonal labeling of circular RNAs
- Break Wave lithotripsy to fragment large kidney stones
Research funding history
8 SBIR/STTR records share this UEI (2016–2021). Reported award amounts total $6,255,660. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services