SBIR/STTR Research Award
Directed evolution of N-terminal amino acid binding proteins for application to protein sequencing
Award amount
$1,473,890Program and phase
SBIR · Phase IIAward year
2020Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- ENCODIA INC
- Proposal award date
- 2020-02-01
- Contract end date
- 2022-01-31
- UEI
- XQMHALBLACC9
- Solicitation number
- PA18-574
- Topic code
- 300
Research abstract
ABSTRACT
More accessible and cost-effective technologies for analysis of the proteome would
accelerate biological and medical research. The goal of this proposal is to develop a
highly-scalable digital protein analysis technology. The approach is broadly applicable
and greatly improves upon cost, sensitivity, usability, and throughput of current
approaches.NARRATIVE
This proposal is to develop technology to enable user-friendly, high-throughput analysis
of proteins. By making information about proteins more easily accessible, this
technology has the potential to advance basic research in almost every area in
molecular life sciences, as well as applied and clinical research, including drug target
discovery and drug development.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- HT protein profiling with a Next-Gen Protein Assay (NGPA)
- Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing.
- Development of Engineered Trypsin for Proteomics Sample Prep.
- Development of Population Level Serotyping Technology and Antibody Profiling for Infectious Pathogens with focus on Influenza and SARS-CoV-2
- Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- A platform for T-cell receptor mimic antibody generation modeled using pHLA-A*11:01 KRAS G12D
- Combinatorial pipeline for discovery of anti-GPCR Nanobodies
- Development of a GBP-based glycosylation analysis system
- Extended-release injectable gel for multi-day treatment of postoperative pain
- eMOA: A Multi-Omic Service for Mechanism of Action Determination in Drug Screening
Research funding history
8 SBIR/STTR records share this UEI (2016–2021). Reported award amounts total $6,255,660. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services