SBIR/STTR Research Award
Optimized Platforms for Proper Glycosylation and Sialylation of Recombinant Human Butyrylcholinesterase (rBChE)
Award amount
$167,499Program and phase
SBIR · Phase IAward year
2020Award details
- Awarding agency
- Department of Defense
- Branch
- Office for Chemical and Biological Defense
- Recipient company
- Technology Holding, LLC
- Proposal award date
- 2020-04-10
- Contract end date
- 2020-10-10
- UEI
- U52NGYKN42H6
- Solicitation number
- 19.2
- Topic code
- CBD192-007
Research abstract
The threat of organophosphate (OP) chemical warfare agents (CWA) to United States military personnel is a persistent problem due to the relative ease of manufacturing chemical threats compared to nuclear and biological agents. Human butyrylcholinesterase (BChE) has been identified as a probable bio-scavenger of OP CWAs that could be used to protect individuals that could be exposed to OP CWAs. The goal of this project is to generate a mammalian cell line capable of expressing human BChE in tetrameric form with appropriate human glycosylation patterns . To achieve this goal we will utilize a triple pronged approach with multiple cell lines currently used to produce human therapeutic proteins. Each approach will be evaluated to determine technical and economic applicability to full scale manufacturing.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- High Energy Density Synthetic Fuel
- Novel Method to Produce Renewable JP10
- HoodLab - A system for neighborhood scale environmental data visualization, crowdsourcing and data exploration tool using edge processing for real-time updates
- Honeycomb Hollow Carbon Fiber Composites
- Innovative Method for Development of Hemp based Fabric
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Optimized Platforms for Proper Glycosylation and Sialylation of Recombinant Human Butyrylcholinesterase (rBChE)
- Production of a stable recombinant human butyrylcholinesterase
- Optimized Platforms for Proper Glycosylation and Sialylation of Recombinant Human Butyrylcholinesterase (rBChE)
- Production of a stable recombinant human butyrylcholinesterase
Research funding history
138 SBIR/STTR records share this UEI (1983–2025). Reported award amounts total $44,688,257. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Defense, Department of Energy, National Science Foundation, National Aeronautics and Space Administration, Environmental Protection Agency, Department of Agriculture