Non-Invasive Monitoring of Changes in Intracranial Pressure Due to Infections in the Central Nervous System

Infections of the central nervous system (CNS) are associated with brain swelling and increased cerebral blood volume, as well as focal cerebral perfusion deficits, variable levels of cerebral blood flow and cerebral vasculitis. The net result is increased intracranial pressure (ICP) along with significant risk of brain tissue herniation and ischemic syndromes. ICP monitoring is critical in the management of CNS infections. While invasive ICP measurements through direct access to the cranium using catheters provide reliable ICP measurements, it involves complicated clinical procedures, restricts patient mobility and risks of infection. The goal of the program is to develop and demonstrate the feasibility of a device that can non-invasively track changes in ICP associated with CNS infections. The proposed device measures the ICP based on high-resolution optical and ultrasound characterization of the carotid and cerebral arteries. The solution will be integrated into ambulatory devices worn on the head and/or around the neck.