Ultrasound-facilitated endovascular laser thrombolysis

AbstractThrombosis affectstopatients in the United States annuallyand results in more thandeaths each yearRapid and complete removal of blood clots to re canalize blood vessels is criticalThe goal of this study is to develop a high efficient endovascular method to remove blood clots by combining laser and ultrasound techniquesCavitation is the main mechanism for both laser and ultrasound thrombolysisLaser based thrombolysis can easily produce vapor cavitation bubblesbut the collapse of these vapor bubbles are not as strong as the ones produced in an acoustic field because there is no driving forceUltrasoundbased thrombolysis can drive cavitation bubbles to strong collapse and generate strong local forcesbut it is very difficult for ultrasound to nucleate cavitation bubbles in the blood because of lack of cavitation nucleiThe combination of laser and ultrasound can therefore overcome the limitations of both thrombolysis techniquesWe propose to develop an ultrasound facilitated endovascular laser thrombolysis techniqueand test and optimize the technique in a series of in vitro and in vivo studiesThe specific aims of the current study aredevelop a prototype device based on photo enhanced ultrasound thrombolysis techniquein vitro studyandevaluate photo enhanced ultrasound thrombolysis in an animal modelSuccessful completion of this project will allow us to develop a highly efficient thrombolysis system to treat blood clot and re canalize blood vessels in clinicsThis project can potentially contribute to the many other applications including treatment and prevention of strokepulmonary embolismand other vascular diseases caused by the narrowing of blood vessels Project NarrativeThe goal of this study is to develop a high efficient endovascular method to remove blood clots by combining laser and ultrasound techniquesSuccessful completion of this project will result in a novel technique to re canalize blood vesselsThis project can potentially contribute to the treatment and prevention of deep vein thrombosisstrokepulmonary embolismand other vascular diseases caused by the narrowing of blood vessels