Microplate bioreactor for high throughput biopharmaceutical process development

AbstractApplications such as industrial bioprocess developmentpersonalized therapies and Design of ExperimentsDoErequire high throughput and the capacity for high cell density growth under controlled conditionsThe landscape of devices used for lab cultivations include bench scale reactorsshake flasksand microtiter platesThese technologies are not amenable to high throughput and are therefore impractical for bioprocess optimization and screening for variation in patient derived starting materialsMicrobioreactor technology presents the opportunity to develop disposable and miniature versions of bench scale reactorswhile maintaining a small footprint in clean roomsMixing is notoriously a challenge in small volume systems and microbioreactor technology has been limited by the inability to achieve predictive scale up in mammalian cell cultureHereRedbud Labs proposes a microplate reactor that uses our novel microfluidic mixerMXRas an integrated impellerOur goal is to optimize oxygen mass transferkLafor predictive scale up to larger reactorsIf successfulour single use microplate system will enable rapid and high throughput raw material screening and improve bioprocesses development NARRATIVE The availability of high throughput microplate bioreactor will revolutionize bioprocess development and enable rapid and inexpensive raw material screening for cell based therapiesRedbud Labs will use our microfluidic mixerMXRas an impeller to optimize oxygen mass transfer and cell growth