A Novel, Point-of-Care, Multi-Analysis Platelet Function Diagnostic System

Platelets play a central role in hemostasis and are responsible for many inherited and acquired bleeding disorders and thrombic events in human beings. A significant portion of post-trauma deaths are related to coagulopathy or hemorrhage events for both injured soldiers and civilian patients. Several platelet function analyzers have been designed and developed; however due to form-factor and/or limited analysis capabilities these systems do not function effectively as point-of-care (POC) instruments. There is a critical need to develop effective POC instrumentation for platelet function assessment to aid in minimizing patient mortality. Lynntech proposes to develop a novel, rapid, easy-to use, and cost effective POC device to simultaneously measure the individual platelet receptor contributions to platelet coagulation in whole blood through an electrochemical-fluidics system. The system automation will be designed such that a single, small blood sample will be fully analyzed within a disposable cartridge to minimize user effort and error.