Low/No Power Detector for Organophosphate Nerve Agents

Organophosphate (OP) nerve agents are the most dangerous chemical warfare agents and therefore pose a significant threat. Rapid and exact identification of the OP agent involved in any hazardous material incident could significantly facilitate the administration of the most effective therapeutic and allow for appropriate measures of protection and decontamination, thereby increasing survival of the warfighter. Luna is proposing to develop a novel no-power colorimetric paper-based sensor that can selectively and sensitively differentiate organophosphate agents (OP). The proposed colorimetric OP sensor (COPS) will be inexpensive, low-volume, portable, disposable, resistant to harsh conditions (high and low temperature), long self-life, and easy-to-use with instantaneous response. In phase I, Luna will develop science behind the recognition elements needed in the detector for capability to differentiate between four OPs in the presence of interferents and from a variety of sources. In Phase II, Luna will develop a sensor capable of distinguishing between four OP agents and three simulants. Luna’s detection technology can also be tailored to other chemical and biological agents of interests.