SBIR/STTR Research Award
Nanocrystal FRET Probes for Multi-Wavelength Analysis of Protein Dynamics
Award amount
$98,948Program and phase
SBIR · Phase IAward year
2006Award details
- Awarding agency
- Department of Defense
- Branch
- Defense Advanced Research Projects Agency
- Recipient company
- LUNA INNOVATIONS INCORPORATED
- Proposal award date
- 2006-12-14
- Contract end date
- 2007-08-14
- UEI
- SJHFCDGKJJC5
- Solicitation number
- 2006.2
- Topic code
- SB062-004
Research abstract
Luna Innovations will demonstrate the feasibility of using a novel set of nanoparticle fluorescence resonant energy transfer (FRET) probes to monitor protein dynamics via real-time single-molecule spectroscopy. The proximity-dependent FRET-like interaction between nanoparticles would translate into time-dependent spectroscopic monitoring of changes in a protein molecule’s shape. The nanoparticle emitters will meet the following probe constraints: fluorescence FWHM less than 10 nm, probe diameter less than 3 nm, photoluminescence quantum yield (PLQY) greater than 90%, suspension in water, conjugation with antibodies. Strategies for optimizing the synthesis of these nanoparticles specifically for this application will be reviewed.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Rugged Miniature SWDM Mux and Demux for Military Aircraft
- Advanced Distributed Fiber Optic Sensing (DFOS) for Naval Safety
- Distributed Linear and Angular Acceleration Measurement
- Terahertz Imaging for Detection of Corrosion and Defects Under Hull Coatings
- Multi-Modal SHM of Inflatable Habitats via Embedded Fiber Optics Sensing
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
Research funding history
994 SBIR/STTR records share this UEI (1991–2026). Reported award amounts total $336,438,763. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Defense, National Aeronautics and Space Administration, Department of Energy, Department of Health and Human Services, National Science Foundation, Environmental Protection Agency