SBIR/STTR Research Award
Next generation spatial genomics tools for the human brain
Award amount
$1,244,076Program and phase
SBIR · Phase IIAward year
2025Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- SPATIAL GENOMICS, INC.
- Proposal award date
- 2025-06-01
- Contract end date
- 2027-05-31
- UEI
- C2CPGG8RZLV9
- Solicitation number
- PA24-245
- Topic code
- 101
Research abstract
SUMMARY Spatial genomics in human brain tissues has the ability to visualize gene expression programs in complex cell interactions that are involved in many neurological disorders. However, current spatial technology is often limited by the high autofluorescence in human brain samples and the poor RNA quality. At Spatial Genomics, we have commercialized the Gene Positioning System (GenePS) platform that is based on the sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows 10,000 genes to be imaged directly in tissue samples. The major goal of this project is to develop next generation reagents to scale up the multiplexity of assays available on the GenePS instrument. We will develop new assays that can be performed robustly across human brain tissues by the GenePS platform.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Spatial single cell analysis of the human Alzheimer's Disease brain
- Spatial genomics analysis of tumor samples
- Multi-modal spatial genomics in the mouse and human brains
- Spatial Genomics for in situ single cell expression analysis in the brain
- Spatial and single cell analysis of tumor microenvironment by seqFISH+
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- High bandwidth all-optical electrophysiology
- Fast multicolor confocal fluorescence imager for neural network mapping
- Advanced culture and recording system for long-term electrophysiological profiling in human brain organoids
- Commercialization Readiness for a Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging
- Design and Development of an Advanced Functional MRI Software as Medical Device (SaMD) forClinical Trials and Therapeutic Applications in Neuropsychiatry
Research funding history
7 SBIR/STTR records share this UEI (2018–2025). Reported award amounts total $13,546,078. Reported amounts are not federal obligations.
Phases: Phase II, Phase I, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services