SBIR/STTR Research Award
Spatial single cell analysis of the human Alzheimer's Disease brain
Award amount
$2,458,626Program and phase
SBIR · Phase IIAward year
2023Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- SPATIAL GENOMICS, INC.
- Proposal award date
- 2023-09-21
- Contract end date
- 2025-05-31
- UEI
- C2CPGG8RZLV9
- Solicitation number
- PAS22-196
- Topic code
- NIA
Research abstract
SUMMARY The major goal of this project is to study human Alzheimer’s Disease (AD) brains using the Spatial Genomics GenePS instrument for automated large scale gene expression analysis at single cell resolution. At Spatial Genomics, we are commercializing the sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows thousands of genes to be imaged directly in brain samples. We have experience working with human brains with our seqFISH technology and will hone the technology for use in human brains. Using the seqFISH method, we will identify changes in cell types, spatial organization of groups of cells, and signaling interactions between neighboring cells in the human AD brain.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Next generation spatial genomics tools for the human brain
- Spatial genomics analysis of tumor samples
- Multi-modal spatial genomics in the mouse and human brains
- Spatial Genomics for in situ single cell expression analysis in the brain
- Spatial and single cell analysis of tumor microenvironment by seqFISH+
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Evaluate the Safety, Tolerability, and Immunogenicity of Adjuvanted Preventive Dual Aβ/tau Vaccine, Duvax in Healthy Volunteers
- A Drug Discovery Platform to Prioritize Development of Natural Product Neuromodulators for Treating Cognitive Impairment
- VR-CARES: Feasibility of Virtual Reality for Caregiver Assembly, Relief, Empowerment, and Support to improve social connection, health, and at-home dementia care
- Developing an Integrated Brain State Monitor for Personalized Anesthesia Decision Support: Preventing Postoperative Delirium in Elderly and Patients At Risk for Alzheimer's or Related Dementias
- Lead Optimization of a Therapeutic Candidate for Alzheimer’s Disease
Research funding history
7 SBIR/STTR records share this UEI (2018–2025). Reported award amounts total $13,546,078. Reported amounts are not federal obligations.
Phases: Phase II, Phase I, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services