NCATS SBIR 2019 PHASE I PROPOSALS TOPIC 018 ENTITLED NON-PDMS BIOCOMPATIBLE ALTERNATIVES FOR ORGANS-ON-CHIPS

Microfluidic organ on a chipOOCsystems offer a distinct advantage over existing in vitro systems through incorporation of micro architecture to a cultured cell line sthat structurely and mechanically mimic more closely in vivo physiological conditions in an in vitro constructThese OOC devices are typically constructed from polydimethylsiloxanePDMShoweverPDMS has several drawbacks that can impact the operational potential of OOCs including non specific absorption of proteins and hydrophobic small moleculesgas permeabilityand evaporationThere is a significant need to replace PDMS use in OOC devicesThe overall objective of this research effort is to demonstrate biocompatible alternate substrate material sfor use in construction of OOC devices that share many of benefits of PDMS without the operational limitationsAs the research effort progresses the operational capabilities of the proposed technology will expand and transition into OOC commercial research tools for in vitro organ functionalityorgan disease statesand toxicological and pharmacological impact on diseasedorgan statesThe final product is expected to be an easy to use material substrate spackage that allows researchers to construct OOC devices to research complex physiology of the desired in vivo organ sand impact of drugsdiseasestoxinsetcin vitro