SBIR/STTR Research Award
Driven Feedback Enhanced Magnetic Resonance Spectroscopic Quantification of Non-Radioactive 19 FDG in Tumors
Award amount
$299,173Program and phase
SBIR · Phase IAward year
2020Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- MILLIKELVIN TECHNOLOGIES, LLC
- Proposal award date
- 2020-09-30
- Contract end date
- 2021-05-31
- UEI
- NDANTBWE8SH5
- Solicitation number
- PA19-272
- Topic code
- NIBIB
Research abstract
Positron Emission Tomography (PET) of radioactive 18FDG is used today to monitor metabolic activity in tumors
and stratify lesion risk via a quantity known as Total Lesion Glycolysis (TLG); however, assessment of TLG using
PET has intrinsic sources of error and requires subjecting the patient to a radioactive burden. Non-radioactive
19FDG could, in theory, be used to produce similar information with less sources of error and no radioactive
burden using Magnetic Resonance Spectroscopy (MRS) to quantify 19F content in tumors; however the signal
from 19F MRS is small compared to 18FDG PET. This project will establish MKT’s novel “dual-frequency
feedback” (DF-FB) novel MRS technique as a sensitive method for detecting 19F spins using MRS, this will allow
19FDG dosage to be minimized and lay the foundation for further R+D where TLG assessed by a) 19F MRS and
b) 18F PET can be rigorously compared.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- A Novel Method For Producing 15N Enriched NH3 For Manufacture of U15N Accident Tolerant Fuel
- Improved Imaging of an MR Molecular Agent Using Driven Feedback Contrast Enhancement
- Enabling Metabolic Imaging Using Feedback Driven Magnetic Resonance Spectroscopy
- Manufacture and Supply of Hyperpolarized Chloroform for Use as an NMR Solvent
- Enabling Metabolic Imaging Using Hyperpolarized 13C Magnetic Resonance
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Deep-UV Microscopy for Real-Time Adequacy Analysis of Bone Marrow Aspirates
- Deep learning image classification model for pediatric ear disease
- Development of a Multispectral Kerrison Rongeur for Dura and Nerve Root Detection
- Non Invasive Urine Output Monitor
- SoundScape: A portable small animal imager to accelerate drug development
Research funding history
6 SBIR/STTR records share this UEI (2009–2020). Reported award amounts total $1,303,402. Reported amounts are not federal obligations.
Phases: Phase I
Agencies: Department of Health and Human Services, Department of Energy