Multi-Cell Human 3D Brain Model on Chip

Warfighter cognitive function and performance can be negatively impacted by stresses that increase risks to warfighters during missions. Significant efforts are being made to understand the effect of stressors on individual warfighters to create efficient countermeasures. However, the study of stressors is often difficult and/or dangerous at the whole-body level. As such, researchers turn to in vitro cellular models. In the case of the human brain, in particular the neurological system associated with cognition, these in vitro models are simplistic and require additional advancement to improve correlation between the in vitro and in vivo physiological system. To address this need, Lynntech is proposing to develop an advanced in vitro brain model incorporating multiple cell types related to learning, memory, neural plasticity, and neurogenesis. It is the intent of this new in vitro model to be compatible with higher throughput analysis to improve understanding of human cognitive systems and allow development of next generation countermeasures to maximize warfighter performance.