Multiplex Detection of MDROs and Lower Intestinal Microbiome Disruption

The balance of the intestinal microbiome is important to human health Antibiotics can disrupt the microbiome and induce colonization by multidrug resistant organisms MDROs The ability to quickly identify disruption and or colonization or the risk of colonization could result in rapid targeted treatment This could reduce the duration of isolation upon admittance transmission risk days length of the hospital stay and complications Lynntech proposes to further develop a user friendly sensitive multiplexed quantitative assay capable of detecting major microbiome microorganisms and MDROs We will utilize this diagnostic to test rectal swabs from patients at risk for MDRO colonization to determine their level of microbiome disruption and if when they become colonized with a MDRO Based on these results we will plan a future study incorporating fecal microbiota transplantation into the treatment plan We will also perform an infection control based intervention demonstration based on environmental samples taken from rooms of MDRO colonized patients Lynntech s effort will result in a multiplexed diagnostic assay capable of rapidly detecting microbiome disruption and or the presence of MDROs in clinical samples This will provide a rapid sample to answer for the patient resulting in appropriate treatment for the patient ultimately limiting the further spread of MDROs